publications - Tzar Labs

Initiation of Cancer: The Journey From Mutations in Somatic Cells to Epigenetic Changes in Tissue-resident VSELs

Multiple theories exist to explain cancer initiation, although a consensus on this is crucial for developing effective therapies. …Thus tissue-resident VSELs offer a connection between extrinsic insults and variations in cancer incidence reported in various body t …

Bhartiya D, Raouf S, Pansare K, Tripathi A, Tripathi A.

Stem Cell Rev Rep. 2024 May;20(4):857-880. doi: 10.1007/s12015-024-10694-7. Epub 2024 Mar 8.

PMID: 38457060.

Quest for Pan-Cancer Diagnosis/Prognosis Ends with HrC Test Measuring Oct4A in Peripheral Blood

Cancer stem cells (CSCs) that initiate cancer are possibly the ‘transformed’ and pluripotent very small embryonic-like stem cells (VSELs) that also express OCT-4A. Excessive self-renewal of otherwise quiescent, pluripotent VSELs in normal tissues possibly initiates …

Tripathi V, Bhartiya D, Vaid A, Chhabria S, Sharma N, Chand B, Takle V, Palahe P, Tripathi A.

Stem Cell Rev Rep. 2021 Oct;17(5):1827-1839. doi: 10.1007/s12015-021-10167-1. Epub 2021 May 6.

PMID: 33954878.

Very Small Embryonic-Like Stem Cells Transform Into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test

Many imponderables exist about whether somatic mutations initiate cancer, do cancer stem cells (CSCs) exist, and if yes, are they a result of de-differentiation or originate from tissue-resident stem cells; why do cancer cells express embryonic markers, and w …

Bhartiya D, Sharma N, Dutta S, Kumar P, Tripathi A, Tripathi A.

Stem Cells. 2023 Apr 25;41(4):310-318. doi: 10.1093/stmcls/sxad015.

PMID: 36881778.

Reversing Uteropathies Including Cancer-Like Changes in Mice by Transplanting Mesenchymal Stromal Cells or XAR Treatment

Neonatal exposure of mouse pups to endocrine disruption cause stem/progenitor cells to undergo epigenetic changes, excessive self-renewal, and blocked differentiation that results in various uteropathies including non-receptive endometrium, hyperplasia, endometriosis, adenomyosis …

Singh P, Metkari SM, Tripathi A, Bhartiya D.

Stem Cell Rev Rep. 2024 Jan;20(1):258-282. doi: 10.1007/s12015-023-10632-z. Epub 2023 Oct 2.

PMID: 37779174.

Very small embryonic-like stem cells have the potential to win the three-front war on tissue damage, cancer, and aging

The concept of dedifferentiation and reprogramming of mature somatic cells holds much promise for the three-front “war” against tissue damage, cancer, and aging. It was hoped that reprogramming human somatic cells into the induced pluripotent state, along with the use of e …

Bhartiya D, Jha N, Tripathi A, Tripathi A.

Front Cell Dev Biol. 2023 Jan 4;10:1061022. doi: 10.3389/fcell.2022.1061022.

PMID: 36684436; PMCID: PMC9846763.

Extremely Active Nano-formulation of Resveratrol (XAR™) attenuates and reverses chemotherapy-induced damage in mice ovaries and testes

BACKGROUND: Fertility preservation and restoration in cancer patients/survivors is the need of present times when increased numbers of patients get cured of cancer but face infertility as a serious side effect. …CONCLUSIONS: The results of the present study potent …

Chhabria S, Takle V, Sharma N, Kharkar P, Pansare K, Tripathi A, Tripathi A, Bhartiya D.

J Ovarian Res. 2022 Oct 21;15(1):115. doi: 10.1186/s13048-022-01043-8. Retraction in: J Ovarian Res. 2023 Mar 24;16(1):61. doi: 10.1186/s13048-023-01138-w.

PMID: 36271409; PMCID: PMC9585716.

Stem Cells and Progenitors in Human Peripheral Blood Get Activated by Extremely Active Resveratrol (XAR™)

XAR is a promising molecule that has the potential to activate pluripotent VSELs and tissue committed adult stem cells ‘progenitors’ resulting in the rejuvenation of various body tissues and for improved, cancer-free health with advanced age….

Tripathi V, Chhabria S, Jadhav V, Bhartiya D, Tripathi A.

Stem Cell Rev Rep. 2018 Apr;14(2):213-222. doi: 10.1007/s12015-017-9784-7.

PMID: 29177909.

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